自动生物医学图像分析的领域至关重要地取决于算法验证的可靠和有意义的性能指标。但是，当前的度量使用通常是不明智的，并且不能反映基本的域名。在这里，我们提出了一个全面的框架，该框架指导研究人员以问题意识的方式选择绩效指标。具体而言，我们专注于生物医学图像分析问题，这些问题可以解释为图像，对象或像素级别的分类任务。该框架首先编译域兴趣 - 目标结构 - ，数据集和算法与输出问题相关的属性的属性与问题指纹相关，同时还将其映射到适当的问题类别，即图像级分类，语义分段，实例，实例细分或对象检测。然后，它指导用户选择和应用一组适当的验证指标的过程，同时使他们意识到与个人选择相关的潜在陷阱。在本文中，我们描述了指标重新加载推荐框架的当前状态，目的是从图像分析社区获得建设性的反馈。当前版本是在由60多个图像分析专家的国际联盟中开发的，将在社区驱动的优化之后公开作为用户友好的工具包提供。

Encoder-解码器神经网络架构设计的最新进展导致了广泛的医学图像分割任务中的显着性能改进。然而，给定任务的最先进的网络可能太需要运行经济实惠的硬件，因此用户通常通过修改各种宏观级别的设计方面来验证实用的解决方法。两个常见示例是对输入图像的下采样，并减少网络深度以满足计算机内存约束。在本文中，我们调查这些变化对细分性能的影响，并显示图像复杂性可以用作选择最适合给定数据集的指导方针。我们考虑了四项统计措施来量化图像复杂性，并评估其在十个不同的公共数据集上的适用性。出于我们的实验的目的，我们还提出了两个新的编码器解码器架构，代表浅层和深度网络，这些宽度比目前流行的网络更高效。我们的研究结果表明，中位数是决定可接受的输入下采样因子和网络深度的最佳复杂性度量。对于高复杂性数据集，在原始图像上运行的浅网络可以产生比在下采样的图像上运行的深网络的更好的分段结果，而相反可能是低复杂性图像的情况。

尽管自动图像分析的重要性不断增加，但最近的元研究揭示了有关算法验证的主要缺陷。性能指标对于使用的自动算法的有意义，客观和透明的性能评估和验证尤其是关键，但是在使用特定的指标进行给定的图像分析任务时，对实际陷阱的关注相对较少。这些通常与（1）无视固有的度量属性，例如在存在类不平衡或小目标结构的情况下的行为，（2）无视固有的数据集属性，例如测试的非独立性案例和（3）无视指标应反映的实际生物医学领域的兴趣。该动态文档的目的是说明图像分析领域通常应用的性能指标的重要局限性。在这种情况下，它重点介绍了可以用作图像级分类，语义分割，实例分割或对象检测任务的生物医学图像分析问题。当前版本是基于由全球60多家机构的国际图像分析专家进行的关于指标的Delphi流程。

There are multiple scales of abstraction from which we can describe the same image, depending on whether we are focusing on fine-grained details or a more global attribute of the image. In brain mapping, learning to automatically parse images to build representations of both small-scale features (e.g., the presence of cells or blood vessels) and global properties of an image (e.g., which brain region the image comes from) is a crucial and open challenge. However, most existing datasets and benchmarks for neuroanatomy consider only a single downstream task at a time. To bridge this gap, we introduce a new dataset, annotations, and multiple downstream tasks that provide diverse ways to readout information about brain structure and architecture from the same image. Our multi-task neuroimaging benchmark (MTNeuro) is built on volumetric, micrometer-resolution X-ray microtomography images spanning a large thalamocortical section of mouse brain, encompassing multiple cortical and subcortical regions. We generated a number of different prediction challenges and evaluated several supervised and self-supervised models for brain-region prediction and pixel-level semantic segmentation of microstructures. Our experiments not only highlight the rich heterogeneity of this dataset, but also provide insights into how self-supervised approaches can be used to learn representations that capture multiple attributes of a single image and perform well on a variety of downstream tasks. Datasets, code, and pre-trained baseline models are provided at: https://mtneuro.github.io/ .

Logic Mill is a scalable and openly accessible software system that identifies semantically similar documents within either one domain-specific corpus or multi-domain corpora. It uses advanced Natural Language Processing (NLP) techniques to generate numerical representations of documents. Currently it leverages a large pre-trained language model to generate these document representations. The system focuses on scientific publications and patent documents and contains more than 200 million documents. It is easily accessible via a simple Application Programming Interface (API) or via a web interface. Moreover, it is continuously being updated and can be extended to text corpora from other domains. We see this system as a general-purpose tool for future research applications in the social sciences and other domains.

In this paper we take the first steps in studying a new approach to synthesis of efficient communication schemes in multi-agent systems, trained via reinforcement learning. We combine symbolic methods with machine learning, in what is referred to as a neuro-symbolic system. The agents are not restricted to only use initial primitives: reinforcement learning is interleaved with steps to extend the current language with novel higher-level concepts, allowing generalisation and more informative communication via shorter messages. We demonstrate that this approach allow agents to converge more quickly on a small collaborative construction task.

High content imaging assays can capture rich phenotypic response data for large sets of compound treatments, aiding in the characterization and discovery of novel drugs. However, extracting representative features from high content images that can capture subtle nuances in phenotypes remains challenging. The lack of high-quality labels makes it difficult to achieve satisfactory results with supervised deep learning. Self-Supervised learning methods, which learn from automatically generated labels has shown great success on natural images, offer an attractive alternative also to microscopy images. However, we find that self-supervised learning techniques underperform on high content imaging assays. One challenge is the undesirable domain shifts present in the data known as batch effects, which may be caused by biological noise or uncontrolled experimental conditions. To this end, we introduce Cross-Domain Consistency Learning (CDCL), a novel approach that is able to learn in the presence of batch effects. CDCL enforces the learning of biological similarities while disregarding undesirable batch-specific signals, which leads to more useful and versatile representations. These features are organised according to their morphological changes and are more useful for downstream tasks - such as distinguishing treatments and mode of action.

Objective: Imbalances of the electrolyte concentration levels in the body can lead to catastrophic consequences, but accurate and accessible measurements could improve patient outcomes. While blood tests provide accurate measurements, they are invasive and the laboratory analysis can be slow or inaccessible. In contrast, an electrocardiogram (ECG) is a widely adopted tool which is quick and simple to acquire. However, the problem of estimating continuous electrolyte concentrations directly from ECGs is not well-studied. We therefore investigate if regression methods can be used for accurate ECG-based prediction of electrolyte concentrations. Methods: We explore the use of deep neural networks (DNNs) for this task. We analyze the regression performance across four electrolytes, utilizing a novel dataset containing over 290000 ECGs. For improved understanding, we also study the full spectrum from continuous predictions to binary classification of extreme concentration levels. To enhance clinical usefulness, we finally extend to a probabilistic regression approach and evaluate different uncertainty estimates. Results: We find that the performance varies significantly between different electrolytes, which is clinically justified in the interplay of electrolytes and their manifestation in the ECG. We also compare the regression accuracy with that of traditional machine learning models, demonstrating superior performance of DNNs. Conclusion: Discretization can lead to good classification performance, but does not help solve the original problem of predicting continuous concentration levels. While probabilistic regression demonstrates potential practical usefulness, the uncertainty estimates are not particularly well-calibrated. Significance: Our study is a first step towards accurate and reliable ECG-based prediction of electrolyte concentration levels.

Inductive reasoning is a core component of human intelligence. In the past research of inductive reasoning within computer science, logic language is used as representations of knowledge (facts and rules, more specifically). However, logic language can cause systematic problems for inductive reasoning such as disability of handling raw input such as natural language, sensitiveness to mislabeled data, and incapacity to handle ambiguous input. To this end, we propose a new task, which is to induce natural language rules from natural language facts, and create a dataset termed DEER containing 1.2k rule-fact pairs for the task, where rules and facts are written in natural language. New automatic metrics are also proposed and analysed for the evaluation of this task. With DEER, we investigate a modern approach for inductive reasoning where we use natural language as representation for knowledge instead of logic language and use pretrained language models as ''reasoners''. Moreover, we provide the first and comprehensive analysis of how well pretrained language models can induce natural language rules from natural language facts. We also propose a new framework drawing insights from philosophy literature for this task, which we show in the experiment section that surpasses baselines in both automatic and human evaluations.

Industry 4.0 aims to optimize the manufacturing environment by leveraging new technological advances, such as new sensing capabilities and artificial intelligence. The DRAEM technique has shown state-of-the-art performance for unsupervised classification. The ability to create anomaly maps highlighting areas where defects probably lie can be leveraged to provide cues to supervised classification models and enhance their performance. Our research shows that the best performance is achieved when training a defect detection model by providing an image and the corresponding anomaly map as input. Furthermore, such a setting provides consistent performance when framing the defect detection as a binary or multiclass classification problem and is not affected by class balancing policies. We performed the experiments on three datasets with real-world data provided by Philips Consumer Lifestyle BV.